Cobian Backup

Cobian Backup is an excellent file backup tool with lots of features. You get full, differential and incremental backups, for instance; zip or 7zip compression; AES 256-bit encryption; include and exclude filters; a strong scheduler, backup to or from FTP servers, and the list goes on. Every aspect of the program is extremely configurable, too (there are more than 100 settings you can tweak).

PC or backup novices are likely to find this a little overwhelming. If you're more experienced, though, you'll love the amount of control Cobian Backup gives you over every aspect of the backup process.